HUMAN GLUTAMATE-RECEPTOR HGLUR3 FLIP AND FLOP ISOFORMS - CLONING AND SEQUENCING OF THE CDNAS AND PRIMARY STRUCTURE OF THE PROTEINS

Authors
RAMPERSAD V ELLIOTT CE NUTT SL FOLDES RL KAMBOJ RK
Citation
V. Rampersad et al., HUMAN GLUTAMATE-RECEPTOR HGLUR3 FLIP AND FLOP ISOFORMS - CLONING AND SEQUENCING OF THE CDNAS AND PRIMARY STRUCTURE OF THE PROTEINS, Biochimica et biophysica acta, N. Gene structure and expression, 1219(2), 1994, pp. 563-566
Citations number
34
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1219
Issue
2
Year of publication
1994
Pages
563 - 566
Database
ISI
SICI code
0167-4781(1994)1219:2<563:HGHFAF>2.0.ZU;2-B
Abstract
Several cDNA clones encoding the human glutamate receptor subunit GluR 3 flip and flop isoforms, were isolated from human hippocampus and fet al brain libraries. DNA sequence analysis revealed overlapping clones permitting the reconstruction of full-length GluR3-flip and GluR3-flop cDNAs. The GluR3 cDNAs demonstrated an 94.1-94.7% nucleotide (nt) ide ntity with the corresponding rat cDNAs. The nt sequence of the GluR3 c DNAs would encode 894 amino acid proteins that have a 99.4% identity w ith the rat GluR3 isoforms. The human GluR3 cDNAs predict an additiona l 6 amino acid in the N-terminal signal peptide as compared to the rat GluR3.