CROSSOVER INTERFERENCE IS ABOLISHED IN THE ABSENCE OF A SYNAPTONEMAL COMPLEX PROTEIN

In the zip1 mutant, meiotic chromosomes fail to synapse, owing to the absence of a structural component of the synaptonemal complex (SC). Th is mutant has been analyzed for the ability to carry out several funct ions that have been proposed for the SC. The data presented show that the zip1 mutation does not affect chiasma function and confers only mo dest defects in meiotic recombination and sister chromatid cohesion. I n contrast, crossover interference is completely abolished in the abse nce of Zip1. These data are the first to establish a molecular link be tween cytological observations of the SC and the genetic phenomenon of interference.