NICOTINE IMPROVES COGNITIVE DISTURBANCE IN SENESCENCE-ACCELERATED MICE

Citation
K. Meguro et al., NICOTINE IMPROVES COGNITIVE DISTURBANCE IN SENESCENCE-ACCELERATED MICE, Pharmacology, biochemistry and behavior, 49(3), 1994, pp. 769-772
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00913057
Volume
49
Issue
3
Year of publication
1994
Pages
769 - 772
Database
ISI
SICI code
0091-3057(1994)49:3<769:NICDIS>2.0.ZU;2-I
Abstract
Senescence-accelerated mice (SAM), a murine model of age-related deter ioration in learning ability, were studied as to the acetylcholine (AC h) contents in the brain tissues and the effect of nicotine administra tion. We found that the ACh content of SAM-P/8 (accelerated senescence -prone) mice was lower than that of SAM-R/1 (accelerated senescence-re sistant) mice in the midbrain thalamus and the hypothalamus. In additi on, an IP administration of nicotine was found to improve learning abi lity of SAM-P/8 as shown by performance of a passive avoidance task. N icotine may potentiate cognitive function in SAM-P/8.