SIDE-EFFECTS OF PEPTIDOGLYCAN MONOMER (PGM) TREATMENT IN MICE

The influence of single (4 mg/mouse) and multiple (1 mg/mouse per day for 5 consecutive days) injections of PGM on some hepatic enzymes, lip id peroxide generation in serum and liver, sialic acid concentration i n serum and spleen and hepatic lysosomal membrane permeability was inv estigated. The studies performed showed that a single injection of PGM in vivo changed temporarily the permeability of lysosomal membranes, lipid peroxidation products and sialic acid concentration, and when ad ministered in vitro modulated superoxide anion production and did not affect the activity of lysosomal membrane enzymes. Multiple injections of PGM did not cause significant changes in the examined parameters. Although the metabolic changes were time-limited and from the toxicolo gical point of view, provoked transient effects, the results obtained may be of importance when using PGM in combined chemo-immunotherapy.