SYNTHESIS OF NOVEL ELLIPTICINE ANALOGS AND THEIR INHIBITION OF MOLONEY LEUKEMIA REVERSE-TRANSCRIPTASE

Authors
TIMARI G SOOS T HAJOS G MESSMER A NACSA J MOLNAR J
Citation
G. Timari et al., SYNTHESIS OF NOVEL ELLIPTICINE ANALOGS AND THEIR INHIBITION OF MOLONEY LEUKEMIA REVERSE-TRANSCRIPTASE, Bioorganic & medicinal chemistry letters, 6(23), 1996, pp. 2831-2836
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
23
Year of publication
1996
Pages
2831 - 2836
Database
ISI
SICI code
0960-894X(1996)6:23<2831:SONEAA>2.0.ZU;2-G
Abstract
Two new ellipticine analogues were synthetized as potential non nucleo side inhibitors of reverse transcriptase and were tested on Moloney le ukaemia virus reverse transcriptase in vitro. Both derivatives (9a,b) showed considerable inhibitory effect; ID50 was found to be in the ran ge of 2.8 to 4.5 x 10(-5) M. \ Copyright (C) 1996 Elsevier Science Ltd