APPLICATION OF THE HECK REACTION IN THE SYNTHESIS OF TRUNCATED NAPHTHOIC ACID RETINOIDS

Authors
YU KL CHEN S OSTROWSKI J TRAMPOSCH KM RECZEK PR MANSURI MM STARRETT JE
Citation
Kl. Yu et al., APPLICATION OF THE HECK REACTION IN THE SYNTHESIS OF TRUNCATED NAPHTHOIC ACID RETINOIDS, Bioorganic & medicinal chemistry letters, 6(23), 1996, pp. 2859-2864
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
23
Year of publication
1996
Pages
2859 - 2864
Database
ISI
SICI code
0960-894X(1996)6:23<2859:AOTHRI>2.0.ZU;2-1
Abstract
A series of truncated naphthoic acid retinoids have been prepared usin g the Heck reaction. These retinoids were evaluated in the RAR transac tivation assay in vitro and in the utriculi reduction assay in vivo. I t has been found that the naphthalene ring of the retinoids is crucial for their retinoid activity and receptor selectivity. Copyright (C) 1 996 Elsevier Science Ltd