EFFECTS OF ESTROGEN ON POTASSIUM-STIMULATED ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS AND OVERLYING CORTEX OF ADULT-RATS

Citation
Rb. Gibbs et al., EFFECTS OF ESTROGEN ON POTASSIUM-STIMULATED ACETYLCHOLINE-RELEASE IN THE HIPPOCAMPUS AND OVERLYING CORTEX OF ADULT-RATS, Brain research, 749(1), 1997, pp. 143-146
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
00068993
Volume
749
Issue
1
Year of publication
1997
Pages
143 - 146
Database
ISI
SICI code
0006-8993(1997)749:1<143:EOEOPA>2.0.ZU;2-N
Abstract
In vivo microdialysis techniques were used to examine the effects of e strogen on potassium-stimulated acetylcholine release in the hippocamp us and overlying cortex of adult, ovariectomized rats. Estrogen treatm ent resulted in a significant increase in the percent change in acetyl choline release induced by potassium relative to controls, particularl y after prolonged (90 min) exposure to high potassium. The data sugges t that estrogen may help to maintain cholinergic function under condit ions where cholinergic afferents to the hippocampal formation and cort ex are challenged or impaired.