Rr. Delacruz et al., NEUROTOXIC LESION OF OCULOMOTOR NEURONS - EVIDENCE FOR REARRANGEMENT OF AXON TERMINALS OF SURVIVING AFFERENT NEURONS, Neurotoxicology, 15(3), 1994, pp. 633-636
The fate of abducens internuclear neurons was studied after the loss o
f their target medial rectus motoneurons of the oculomotor nucleus in
adult cats. Target motoneurons were killed by injecting ricin, a toxic
lectin, into the medial rectus muscle of the eye. The entire populati
on of abducens internuclear neurons survived the loss of target for a
long time (1 year), although they exhibited an initial critical period
after target loss characterized by a marked reduction of afferent syn
aptic transmission. One month later, the normal parameters of synaptic
transmission resumed. In contrast, the density of axonal terminals of
abducens internuclear neurons in the oculomotor nucleus progressively
decreased during the year following target loss. Evidence is presente
d for the reinnervation of a new neuronal target within the oculomotor
nucleus that might support both the long-term survival and the recove
ry of physiological characteristics in the abducens internuclear neuro
ns. (C) 1994 Intox Press, Inc.