TRILINOLEIN INHIBITS EPINEPHRINE-INDUCED HUMAN PLATELET-AGGREGATION

At concentrations ranging from 10(-9) to 10(-6) M, trilinolein inhibit ed epinephrine-induced platelet aggregation. This inhibition was accom panied by reduced ATP release and thromboxane B-2 formation. However, concentration-response curves for the interaction between trilinolein and epinephrine showed that trilinolein was unlikely a competitive ant agonist of epinephrine. Platelet aggregation induced by collagen, thro mbin, ADP or arachidonic acid was not inhibited. This study supported the theory that this type of triglyceride may have therapeutic potenti al but the definite mechanism for its effect remains to be answered.