IMMUNOREACTIVITY TO CHROMOGRANIN AND TO VASOACTIVE-INTESTINAL-PEPTIDEIN A CANINE PHEOCHROMOCYTOMA

Authors
CUERVO L BALAGUER L ROMANO J IDIGORAS I GONZALEZ L
Citation
L. Cuervo et al., IMMUNOREACTIVITY TO CHROMOGRANIN AND TO VASOACTIVE-INTESTINAL-PEPTIDEIN A CANINE PHEOCHROMOCYTOMA, Journal of Comparative Pathology, 111(3), 1994, pp. 327-331
Citations number
10
Categorie Soggetti
Pathology,"Veterinary Sciences
Journal title
Journal of Comparative Pathology → ACNP
ISSN journal
00219975
Volume
111
Issue
3
Year of publication
1994
Pages
327 - 331
Database
ISI
SICI code
0021-9975(1994)111:3<327:ITCATV>2.0.ZU;2-#
Abstract
A canine phaeochromocytoma was diagnosed by (1) argyrophil methods, (2 ) immunoreactivity to chromogranin and to vasoactive intestinal peptid e (VIP), and (3) the demonstration of typical electron-dense granules by transmission electron microscopy. This is the first report of immun oreactivity to general neuroendocrine markers such as chromogranin, an d to VIP, in a phaeochromocytoma in domestic animals. The use of these markers for the differential diagnosis of phaeochromocytoma, and the role of VIP in the severe chronic diarrhoea shown by the dog in this s tudy are discussed.