Ah. Balen et Hs. Jacobs, A PROSPECTIVE-STUDY COMPARING UNILATERAL AND BILATERAL LAPAROSCOPIC OVARIAN DIATHERMY IN WOMEN WITH THE POLYCYSTIC-OVARY-SYNDROME, Fertility and sterility, 62(5), 1994, pp. 921-925
Object: To assess the efficacy of unilateral laparoscopic ovarian diat
hermy in the induction of ovulation in anti-estrogen-resistant polycys
tic ovary syndrome (PCOS). Design: A prospective randomized study was
performed to compare unilateral with bilateral ovarian diathermy. Sett
ing: Specialist Reproductive Endocrine Unit. Patients: Ten patients wi
th anti-estrogen-resistant PCOS. Interventions: Randomization to unila
teral (4 patients) or bilateral laparoscopic ovarian diathermy (6 pati
ents). Main outcome measures: Rate and side of ovulation and change in
endocrine profiles after ovarian diathermy. Results: Unilateral ovari
an diathermy resulted in ovulation from both ovaries. Fifty percent of
the patients responded to diathermy and those who responded had a sig
nificantly greater fall in serum LH concentrations than those who fail
ed to respond. Conclusions: The mechanism of action of laparoscopic ov
arian diathermy is via a correction of disturbed ovarian-pituitary fee
dback. Hypersecretion of LH appears to be the most significant endocri
ne disturbance in these patients.