COCAINE ALTERS PLACENTAL PRODUCTION OF THROMBOXANE AND PROSTACYCLIN

Citation
M. Monga et al., COCAINE ALTERS PLACENTAL PRODUCTION OF THROMBOXANE AND PROSTACYCLIN, American journal of obstetrics and gynecology, 171(4), 1994, pp. 965-969
Citations number
22
Categorie Soggetti
Obsetric & Gynecology
ISSN journal
00029378
Volume
171
Issue
4
Year of publication
1994
Pages
965 - 969
Database
ISI
SICI code
0002-9378(1994)171:4<965:CAPPOT>2.0.ZU;2-V
Abstract
OBJECTIVE: The objective of this study was to test the hypothesis that cocaine alters placental prostaglandin production in vitro. STUDY DES IGN: Placentas were obtained from healthy women (n = 6) after normal v aginal delivery at term. Placental explants (300 mg) were incubated in duplicate at 37 degrees C in the presence of 0, 30, 300, or 3000 ng/m l cocaine. Thromboxane and prostacyclin production was measured by rad ioimmunoassay of their stable metabolites (thromboxane B-2 and 6-keto- prostaglandin F-1 alpha) at 0, 0.5, 1.0, 1.5, 2, 4, 8, and 12 hours. A nalysis of variance with Newman-Keuls test was used for statistical an alysis. RESULTS: Cocaine increased thromboxane production in a dose-de pendent manner (p < 0.001) and decreased prostacyclin production (p < 0.05). Cocaine increased the ratio of thromboxane/prostacyclin product ion (p < 0.05). CONCLUSION: Cocaine alters the placental production of prostaglandins in vitro, favoring thromboxane production, which may c ause vasoconstriction and decrease uteroplacental blood flow.