A BETA-CASEIN GENE FRAGMENT IS LOCATED IN REGION-1P3 OF HUMAN CHROMOSOME-1

Analysis of the nucleotide sequence of a cloned fragment of the human beta-casein gene was performed. A conserved DNA locus, present with a varying degree of degeneracy in introns of [beta]-casein genes of seve ral species and in the intron of an oncogene of the sarc family, was r evealed. It was located in region 1p31-32 by means of in situ hybridiz ation. A clearly visible additional hybridization site was observed in region 1p36. The data obtained are discussed in the light of availabl e information on several oncogenes that are located in region 1p3. A r elation was found between this region and the occurrence of some cance rs, including breast cancer.