N-3 FATTY-ACID DEFICIENCY INCREASES BRAIN PROTEIN-SYNTHESIS IN THE FREE-MOVING ADULT-RAT

Authors
GIAUME M GAY N BAUBET V GHARIB A DURAND G BOBILLIER P SARDA N
Citation
M. Giaume et al., N-3 FATTY-ACID DEFICIENCY INCREASES BRAIN PROTEIN-SYNTHESIS IN THE FREE-MOVING ADULT-RAT, Journal of neurochemistry, 63(5), 1994, pp. 1995-1998
Citations number
18
Categorie Soggetti
Biology,Neurosciences
Journal title
Journal of neurochemistry → ACNP
ISSN journal
00223042
Volume
63
Issue
5
Year of publication
1994
Pages
1995 - 1998
Database
ISI
SICI code
0022-3042(1994)63:5<1995:NFDIBP>2.0.ZU;2-0
Abstract
The autoradiographic method with L-[S-35]methionine was used to determ ine the effects of an n-3 fatty acid deficiency on brain protein synth esis. Brain protein synthesis was significantly increased (from 50 to 150%) in 45 of the 52 brain structures studied in n-3 fatty acid-defic ient rats as compared with control animals. Biochemical analysis confi rmed the increase in overall rate of protein synthesis in brain as a w hole.