DECREASED DENSITY OF ENDOTHELIN BINDING-SITES IN ADRENAL-GLANDS BUT NOT IN AORTA, OF LONG-TERM INFARCTED RATS

Authors
VESCI L MATTERA GG BOTARELLI M TOBIA P CORSICO N MARTELLI EA
Citation
L. Vesci et al., DECREASED DENSITY OF ENDOTHELIN BINDING-SITES IN ADRENAL-GLANDS BUT NOT IN AORTA, OF LONG-TERM INFARCTED RATS, Life sciences, 55(22), 1994, pp. 161200421-161200424
Citations number
11
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
55
Issue
22
Year of publication
1994
Pages
161200421 - 161200424
Database
ISI
SICI code
0024-3205(1994)55:22<161200421:DDOEBI>2.0.ZU;2-#
Abstract
Endothelins (Et-s) are biologically active peptides which play a physi ological and pathological role in the cardiovascular regulation. The a im of our study was to verify, in a model of experimental long term my ocardial ischemia (15 weeks) in rats, whether there was a sites of aor ta and adrenal glands. Additionally, Ang II binding sites in adrenal g lands were studied. The principal finding of the present study was the down-regulation of ET binding sites in adrenal glands of chronic infa rcted rats, whereas no modification of binding parameters for Et-1, in thoracic aorta, nor for Ang II, in adrenal glands, were found.