UROTHELIAL LINED COLOCYSTOPLASTY IN A SHEEP MODEL

Nineteen lambs underwent colocystoplasty using a segment of demucosali sed sigmoid colon, and were compared to 14 control animals. Nine anima ls had a procedure which included the addition of the muscle patch to an autoaugmented bladder, and 10 had a clam cystoplasty with the denud ed colon. Six months after the procedure, the average compliance value for the autoaugmentation colocystoplasty bladders was 5.7 +/- 1.7 ml/ cm H2O, compared to 6.9 +/- 2.2 ml/cm H2O for the clam-demucosalised c olocystoplasty group, and 11.0 +/- 4.8 ml/cm H2O for the control group . Whereas at 12 months the compliance values were 9.2 +/- 3.5, 10.7 +/ - 5.1 and 9.1 +/- 3.7 ml/cm H2O for each of the groups, respectively. The sheep colonic muscle tolerated the demucosalisation procedure poor ly, reflected in an inflamed, haemorrhagic colonic segment in the anim als sacrificed within 1 month; this may have been the reason for the p oor results, and explain why the autoaugmentation did not improve the outcome. Colonic mucosal regrowth occurred in 5, and was related to th e demucosalisation technique.