A MYASTHENIC-LIKE SYNDROME IN YOUNG RELATED MONGREL DOGS

A myasthenic-like syndrome is reported in two mongrel litter mates. Th e condition was manifested clinically as intermittent, exercise relate d, and progressive muscle weakness. Neurological abnormalities were re lated to the muscle weakness. Electrophysiologically, there was a decr ement of the muscle action potential during repetitive nerve stimulati on. Antibodies directed against acetylcholine receptors were not demon strable in serum. Treatment with a long-acting cholinesterase inhibito r resulted in temporary improvement.