SUPPRESSION OF PIPERIDINE-MEDIATED SIDE PRODUCT FORMATION FOR ASP(OBU(T))-CONTAINING PEPTIDES BY THE USE OF N-(2-HYDROXY-4-METHOXYBENZYL) (HMB) BACKBONE AMIDE PROTECTION

Authors
QUIBELL M OWEN D PACKMAN LC JOHNSON T
Citation
M. Quibell et al., SUPPRESSION OF PIPERIDINE-MEDIATED SIDE PRODUCT FORMATION FOR ASP(OBU(T))-CONTAINING PEPTIDES BY THE USE OF N-(2-HYDROXY-4-METHOXYBENZYL) (HMB) BACKBONE AMIDE PROTECTION, Journal of the Chemical Society, Chemical Communications, (20), 1994, pp. 2343-2344
Citations number
15
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
20
Year of publication
1994
Pages
2343 - 2344
Database
ISI
SICI code
0022-4936(1994):20<2343:SOPSPF>2.0.ZU;2-Z
Abstract
Piperidine-mediated aspartimide and subsequent piperidide formation, d uring Fmoc-based synthesis of sensitive aspartyl (beta-tert-butyl este r, OBu(t))-containing peptides, is completely suppressed by the use of Hmb protection of the aspartyl amide bond.