FIRST SYNTHESES OF NOVEL PACLITAXEL(TAXOL) ANALOGS MODIFIED AT THE C4-POSITION

Authors
CHEN SH KADOW JF FARINA V FAIRCHILD CR JOHNSTON KA
Citation
Sh. Chen et al., FIRST SYNTHESES OF NOVEL PACLITAXEL(TAXOL) ANALOGS MODIFIED AT THE C4-POSITION, Journal of organic chemistry, 59(21), 1994, pp. 6156-6158
Citations number
48
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
21
Year of publication
1994
Pages
6156 - 6158
Database
ISI
SICI code
0022-3263(1994)59:21<6156:FSONPA>2.0.ZU;2-S
Abstract
A highly regiospecific method for the modification of paclitaxel at th e C-4 position has been invented, as exemplified by the synthesis of t he C-4 cyclopropyl ester of paclitaxel (4) and the C-4 benzoate of pac litaxel (5).