CHLORIOLINS A-C, CHLORINATED SESQUITERPENES PRODUCED BY FUNGAL CULTURES SEPARATED FROM A JASPIS MARINE SPONGE

Three new chlorinated, cyclic sesquiterpenes, chloriolin A (1), B (2), C (3), and two known compounds, coriolin B (4) and dihydrocoriolin C (5), were isolated from an unidentified fungus which was initially sep arated from the marine sponge Jaspis aff. johnstoni and then cultured on marine media. 2D NMR experiments, synthetic transformations, and X- ray crystallography were used to establish the structures of the new c ompounds.