CORRELATION BETWEEN CLINICAL, ELECTROMYOGRAPHIC AND DYSAUTONOMIC EVOLUTION OF FAMILIAL AMYLOIDOTIC POLYNEUROPATHY OF THE PORTUGUESE TYPE

To assess the correlation between the severity of clinical symptoms an d sensorymotor and autonomic function in familial amyloidotic polyneur opathy of the Portuguese type (FAP-PT), clinical grade (CG), electromy ographic score(ES), sympathetic (SS) and parasympathetic score (PS) we re compared in 47 patients. SS and PS were both abnormal in 72% of pat ients with ES = 0% and in 73% of patients with CG = 0. When SS and PS were compared with either CG and ES, PS progressed more rapidly and st abilized earlier than SS. As a whole, SS and PS were greater as CG and ES were higher. This pattern of autonomic involvement should be taken into account when assessing the course of the disease and evaluating new forms of therapy.