NOVEL ANTIBIOTICS, AMYTHIAMICINS .2. STRUCTURE ELUCIDATION OF AMYTHIAMICIN-D

The structure of a unique polythiazole-containing cyclic peptide antib iotic, amythiamicin D, was elucidated by chemical degradations and NMR spectral analyses. Acid hydrolysis of amythiamicin D gave one mole of glycine and three new amino acids. Structures of N-acetyl-O-methyl de rivatives of these new amino acids were determined by NMR and UV spect ral analyses. Connectivities of these amino acids were determined by H MBC experiments.