The biosynthesis of the carbocyclic iridoid glucosides present in the
genus Forsythia has been investigated. Deuterium labelled deoxyloganic
acid, 8-epi-deoxyloganic acid and adoxosidic acid were fed to Forsyth
ia viridissima and F. europaea. These experiments showed that the bios
ynthesis presumably follows a pathway including both deoxyloganic acid
and adoxosidic acid. Two new compounds were isolated from F. europaea
, i.e. 11-glucosyl forsythide and 11-methyl forsythide.