TRANSCRIPTION FACTORS VS NUCLEOSOMES - REGULATION OF THE PH05 PROMOTER IN YEAST

Authors
SVAREN J HORZ W
Citation
J. Svaren et W. Horz, TRANSCRIPTION FACTORS VS NUCLEOSOMES - REGULATION OF THE PH05 PROMOTER IN YEAST, Trends in biochemical sciences, 22(3), 1997, pp. 93-97
Citations number
50
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
22
Issue
3
Year of publication
1997
Pages
93 - 97
Database
ISI
SICI code
0968-0004(1997)22:3<93:TFVN-R>2.0.ZU;2-2
Abstract
Activation of the Saccharomyces cerevisiae PHO5 gene is accompanied by the disruption of four positioned nucleosomes at the promoter. The ch romatin transition requires a DNA-binding protein, Pho4, and its trans activation domain. The mechanism of nucleosome disruption and the cont ribution of the nucleosomes to PHO5 regulation are reviewed.