STRUCTURE AND CHROMOSOMAL LOCALIZATION OF THE HUMAN PD-1 GENE (PDCD1)

A cDNA encoding mouse PD-1, a member of the immunoglobulin superfamily was previously isolated from apoptosis-induced cells by subtractive h ybridization. To determine the structure and chromosomal location of t he human PD-1 gene, we screened a human T cell cDNA library by mouse P D-1 probe and isolated a cDNA coding for the human PD-1 protein. The d educed amino acid sequence of human PD-1 was 60% identical to the mous e counterpart, and a putative tyrosine kinase-association motif was we ll conserved. The human PD-1 gene was mapped to 2q37.3 by chromosomal in situ hybridization. (C) 1994 Academic Press, Inc.