MAPPING OF THE HUMAN SAP1 (SRF ACCESSORY PROTEIN-1) GENE AND SAP2, A GENE ENCODING A RELATED PROTEIN, TO CHROMOSOMAL BANDS 1Q32 AND 12Q23, RESPECTIVELY

SAP1, SAP2, and ELK1 form a related subgroup of ETS-domain proteins th at can form ternary complexes with the transcription factor SRF at the c-fos serum response element (SRE). SAP1 was identified by a genetic screen for proteins interacting with SRF expressed in yeast, and SAPS by its homology with SAP1; ELK1 was previously identified by its homol ogy to the ETS domain. cDNA probes were used to isolate cosmid and pha ge clones harboring genes encoding SAP1 and SAPS. These clones were su bsequently used to map the genes to 1q32 and 12q23, respectively, by f luorescence in situ hybridization. (C) 1994 Academic Press, Inc.