PRETREATMENT WITH THE POLYAMINE ANALOG 1,19-BIS-(ETHYLAMINO)-5,10,15-TRIAZANONADECANE (BE-4-4-4-4) INHIBITS ETOPOSIDE CYTOTOXICITY IN U-251MG (NCI) HUMAN BRAIN-TUMOR CELLS

Authors
SMIRNOV IV FEUERSTEIN BG PELLARIN M MARTON LJ DEEN DF BASU HS
Citation
Iv. Smirnov et al., PRETREATMENT WITH THE POLYAMINE ANALOG 1,19-BIS-(ETHYLAMINO)-5,10,15-TRIAZANONADECANE (BE-4-4-4-4) INHIBITS ETOPOSIDE CYTOTOXICITY IN U-251MG (NCI) HUMAN BRAIN-TUMOR CELLS, Cellular and molecular biology, 40(7), 1994, pp. 975-980
Citations number
41
Categorie Soggetti
Cytology & Histology",Biology
Journal title
Cellular and molecular biology → ACNP
ISSN journal
01455680
Volume
40
Issue
7
Year of publication
1994
Pages
975 - 980
Database
ISI
SICI code
0145-5680(1994)40:7<975:PWTPA1>2.0.ZU;2-R
Abstract
We studied whether pretreatment of U-251 MG human brain tumor cells wi th the polyamine analog 1,19-bis-(ethylamino)-5,10-15-triazanonadecane (BE-4-4-4-4) affected the cytotoxicity of the toposionmerase II inhib itor etoposide. We found that BE-4-4-4-4 protected cells from the cyto toxic effects of etoposide. Possible mechanisms for this protection ma y be related to enhanced DNA-nuclear matrix association in analog-trea ted cells.