The outcome of hemodialysis therapy is usually measured in terms of bi
ochemical responses. Patient well-being, measured as general health st
atus (GHS), can also define outcome. GHS encompasses patients' subject
ive assessment of how health, well-being and function are influenced b
y disease and therapy. GHS can be quantified using the Medical Outcome
s Study Short Form 20 (MOS SF-20). This instrument was administered lo
ngitudinally to our hemodialysis population for 1 year. Significant po
sitive and negative predictors were identified, and case studies illus
trate the influence of these predictors. MOS SF-20 data can also be us
ed to evaluate the effect of therapeutic interventions. The measuremen
t of GHS adds a useful, new dimension to the care of renal patients.