REACTION OF INFLAMED PERIAPICAL TISSUE TO INTRACANAL MEDICAMENTS AND ROOT-CANAL SEALERS

The effects of different intracanal medicaments and zinc oxide-eugenol based root canal sealers on an experimentally induced apical periodon titis were studied histologically in mesial roots of lower molars of W istar rats. After root canal instrumentation each canal was filled eit her with an intracanal medicament twice for 3 days each time or with a sealer for 21 days. The intracanal medicament chlorophenol caused per iapical tissue damage. P-chloroxylenol-camphor lead to periapical impr ovement as did 5% sodium-hypochlorite. 12% sodium-hypochlorite gave ti ssue damage. After intracanal medication with an aqueous suspension of calcium hydroxide periapical repair was clearly visible. A combinatio n of a corticoid and an antibiotic appeared to induce damage of the pe riapical tissues. The root canal sealers Endomethasone and N2 essentia lly impaired periapical repair. The results were acceptable for Aptal- Zink-Harz root canal fillings after 21 days as well as after 56 days.