PATTERNS OF ABNORMAL MYOGENESIS IN HUMAN CLEFT PALATES

Citation
Sr. Cohen et al., PATTERNS OF ABNORMAL MYOGENESIS IN HUMAN CLEFT PALATES, The Cleft palate-craniofacial journal, 31(5), 1994, pp. 345-350
Citations number
4
Categorie Soggetti
Surgery,"Dentistry,Oral Surgery & Medicine
ISSN journal
10556656
Volume
31
Issue
5
Year of publication
1994
Pages
345 - 350
Database
ISI
SICI code
1055-6656(1994)31:5<345:POAMIH>2.0.ZU;2-6
Abstract
To test the hypothesis that soft palate muscles are abnormal in cleft palate, we compared soft palate morphogenesis in fetuses with cleft pa late (n=4) to age-matched (n=3) and nonmatched (n=1) control specimens . The morphologic status of all soft palate and masticatory structures were classified into one of six stages based on the level of histogen esis. At 54 mm crown-rump length (CRL), the levator veli palatini (L), palatopharyngeus (PP), and palatoglossus (PG) in cleft subjects demon strated mesenchymal condensation into myoblastic fields, lagging behin d the control specimens (97 mm CRL), which displayed definitive fields of myoblasts and myotube formation. In the 175 mm and 225 mm cleft an d the 170 mm and 192 mm control specimens, muscular morphology was sim ilar and had reached its postnatal appearance for the tensor veil pala tini (175 m only) and L, PP, PG (225 mm only). Muscle fiber directions were, however, disoriented and disorganized, especially close to the medial epithelial edge of the cleft. The levator veli palatini, could not be distinguished as a discrete muscle in the cleft specimens, and what we believed io be the PP and PG seemed ''normal'' at the level of light microscopy, but malpositioned in a superior direction. This pre liminary study demonstrates for the first time that early myogenesis i n cleft palates differs from normal.