The photomechanical model of laser ablation of biological tissue asser
ts that ablation is initiated when the laser-induced tensile stress ex
ceeds the ultimate tensile strength of the target. We show that, unlik
e the one-dimensional thermoelastic model of laser-induced stress gene
ration that has appeared in the literature, the full three-dimensional
solution predicts the development of significant tensile stresses on
the surface of the target, precisely where ablation is observed to occ
ur. An interferometric technique has been developed to measure the tim
e-dependent thermoelastic expansion, and the results for subthreshold
laser fluences are in precise agreement with the predictions of the th
ree-dimensional model.