SYNTHESIS OF AMINOPHOSPHONOPEPTIDES CONTAINING CARBAPENEM

A new kind of aminophosphonopeptides containing carbapenem, yl-(5R,6S) -3-(2-carbobenzyloxyamino-3-dialkylphos- l}-7-oxo-1-azabicyclo[3.2.0]h ept-2-ene-carboxylate 1a-1d, have been synthesized. no-3-dialkylphosph onopropionyl-2-amino-ethanethiol 7a-7d, aminophosphonopeptides were pr oduced starting from N-carbobenzyloxyserine methyl ester (2) and 2-ami no-3-dialkyl-phosphonopropionate (4) by way of methyl 2-carbobenzyloxy amino-3-dialkylphosphono 5a-5d. The coupling of amino-phosphonopeptide s 7a-7d and allyl -aza-3,7-dioxobicyclo[3.2.0]-heptane-2-carboxylate y ielded aminophosphonopeptides containing carbapenem 1a-1d.