Ad. Vanengelen et al., MANAGEMENT OUTCOME AND FOLLOW-UP OF FETAL TACHYCARDIA, Journal of the American College of Cardiology, 24(5), 1994, pp. 1371-1375
Objectives. The aim of this study was to evaluate fetal tachycardia an
d the efficacy of maternally administered antiarrhythmic agents and th
e effect of this therapy on delivery and postpartum management Backgro
und. Sustained fetal tachycardia is a potentially life-threatening con
dition in which pharmacologic therapy is reported to be effective. The
re is ongoing discussion about optimal management. Methods. A group of
51 patients with M-mode echocardiographically documented fetal tachyc
ardia was studied retrospectively. Results. Thirty-three fetuses had s
upraventricular tachycardia; 15 had atrial flutter; 1 had two episodes
of both; and 2 had ventricular tachycardia. Fetal hydrops was seen in
22 patients. Thirty-four fetuses received maternal therapy with eithe
r digoxin or flecainide as the first administered drug (additional dru
gs were given in 12). Drug treatment was successful in establishing ac
ceptable rhythm control in 82% (84% without, 80% with hydrops). In the
latter group the median number of drugs and number of days to convers
ion were higher. Three patients with fetal hydrops died. In 50% of cas
es, tachycardia reappeared at delivery: 9 neonates presented with atri
al flutter, 14 with supraventricular tachycardia and 1 with ventricula
r tachyeardia. Seventy-eight percent of the group had pharmacologic th
erapy by 1 month of age and 14% by 3 years. Conclusions. Fetal tachyca
rdia can be treated adequately in the majority of patients, even in th
e presence of hydrops, and therefore emergency delivery might not be i
ndicated. Digoxin and flecainide were drugs of first choice and produc
ed no serious adverse effects in this series of patients. The majority
of patients not require prolonged therapy.