THE EFFECTS OF LOXIGLUMIDE ON FOOD-INTAKE IN NORMAL-WEIGHT VOLUNTEERS

The aim of this paper was to investigate the effects of the CCK, a rec eptor antagonist loxiglumide on food intake, hunger and fullness in hu mans. A double blind, placebo controlled, cross-over test was carried out, with subjects taking one loxiglumide or one placebo tablet three times a day, 15 min before main meals or at comparable intervals. The work was carried out at the Centre for Human Nutrition, Northern Gener al Hospital, University of Sheffield, on 11 healthy, normal weight, ma le and female volunteers. The following were measured: weighed-intake measurement of food intake during drug and placebo treatment; laborato ry test of food intake on day three of each treatment; hunger and full ness ratings throughout this meal. A small, non-significant, increase in food intake as measured by the weighed intake diaries (8577 +/- 636 vs 7895 +/- 569 kJ (2049 +/- 152 vs 1886 +/- 136 kcal); P = 0.17) was seen during loxiglumide treatment, but no effect on food consumption from the evening test meal was observed and no effect on feelings of h unger and fullness before or after this meal was seen. These results d o not support the hypothesis that, in the free feeding situation, endo genously released CCK is involved in the reduction of food intake or i nhibition of hunger. However, a different dose of route of administrat ion or a larger group of subjects may reveal an effect of loxiglumide on feeding in humans.