RISK-FACTORS FOR THE DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM) IN JAPAN

Citation
T. Kadowaki et H. Yoshinaga, RISK-FACTORS FOR THE DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES-MELLITUS (NIDDM) IN JAPAN, Diabetes research and clinical practice, 24, 1994, pp. 190000123-190000127
Citations number
14
Categorie Soggetti
Gastroenterology & Hepatology","Endocrynology & Metabolism
ISSN journal
01688227
Volume
24
Year of publication
1994
Supplement
S
Pages
190000123 - 190000127
Database
ISI
SICI code
0168-8227(1994)24:<190000123:RFTDON>2.0.ZU;2-6
Abstract
Follow-up studies of subjects with impaired glucose tolerance in Japan have shown that a higher level of blood glucose is a major predictor of the subsequent development of non-insulin-dependent diabetes mellit us (NIDDM). In addition, subjects with a lower insulin response to glu cose show a higher risk for the development of NIDDM. In fact, most of the subjects who later develop diabetes show a lower insulin response to glucose at the initial examination. Moreover, obesity is generally associated with a higher risk of developing NIDDM. We conclude that l ow insulin secretion forms an important basis and obesity plays a prec ipitating role among low-insulin responders in the pathogenesis of the majority of NIDDM patients in Japan.