According to a nation-wide survey of dialysis patients in Japan the nu
mber of diabetic patients with end-stage renal failure introduced to d
ialysis therapy has been increasing year by year, exceeding 6000 cases
(28% of total cases) in 1991. A six-fold increase in numbers and a th
ree-fold increase in percentages (DM/total) were observed in the past
ten years. Although the medical technology and regimen in dialysis the
rapy have been greatly improved, the prognosis of those diabetic patie
nts on maintenance dialysis has remained unsatisfactory. Their quality
of life has been severely damaged mostly because of the impairment of
visual acuity. The early detection and early introduction of effectiv
e therapy for diabetic nephropathy, therefore, may be the most imminen
t tasks necessary to prevent the various problems afflicting diabetic
patients on end-stage renal failure.