THE INFLUENCE OF NEUROENDOCRINE PATHWAYS ON LYMPHOCYTE MIGRATION

The immunological work that leads to the production of effector cells, immunoglobulins and cytokines in intact animals results from the coor dinated interaction of clusters of specialized lymphocytes. These lymp hoid clusters function in microenvironments within which they may be e xposed to neural and endocrine signals, and the ability of such signal s to modulate the local output of immune labor is now well recognized. Here, Clifford Ottaway and Alan Husband review evidence suggesting th at the output of neuroendocrine pathways has a modulatory effect on th e migratory behavior of lymphocytes in vivo. This can lead to rapid ch anges in the specific phenotypes of lymphocytes accumulating in tissue s and organs undergoing immune challenge.