TREATMENT OF CUTANEOUS T-CELL LYMPHOMA WITH DACARBAZINE IN A DOG

Epitheliotropic cutaneous T-cell lymphoma in a Lhasa Apso dog treated with dacarbazine is reported. Clinical disease consisted of a 4 x 4-cm ulcerated mass over the mandibular symphysis and bilateral lymphadeno pathy of the submandibular lymph nodes. Skin biopsy sections were diag nostic for epitheliotropic cutaneous T-cell lymphoma, and immunohistoc hemistry staining for the CD3 antigen was positive. Tissue samples wer e submitted for chemosensitivity testing and dacarbazine was shown to be 60% effective. Treatment with dacarbazine resulted in total clinica l remission. The dog remains disease free 1 year after treatment.