OSTEOPROMOTION FOR CRANIOPLASTY - AN EXPERIMENTAL-STUDY IN RATS USINGACIDIC FIBROBLAST GROWTH-FACTOR

Citation
P. Cuevas et al., OSTEOPROMOTION FOR CRANIOPLASTY - AN EXPERIMENTAL-STUDY IN RATS USINGACIDIC FIBROBLAST GROWTH-FACTOR, Surgical neurology, 47(3), 1997, pp. 242-246
Citations number
35
Categorie Soggetti
Clinical Neurology",Surgery
Journal title
ISSN journal
00903019
Volume
47
Issue
3
Year of publication
1997
Pages
242 - 246
Database
ISI
SICI code
0090-3019(1997)47:3<242:OFC-AE>2.0.ZU;2-V
Abstract
BACKGROUND Many growth factors influence the bone healing cascade. Fur thermore, the occasional failure of bone repair may in part be due to perturbation in the activation of local growth factors. Local activati on of fibroblast growth factors (FGFs) at the fracture site may serve to increase neovascularization, and induce early granulation formation that can affect bone healing. METHODS We have performed a rat parieta l (6 x 3 mm) critical size defect (CSD). Human recombinant acidic fibr oblast growth factor (hraFGF) imbided in agarose was topically adminis tered at the craniectomy site. Control animals received agarose alone in the same manner. Three weeks after surgery, osteopromotion was hist ologically evaluated. RESULTS hraFGF-treated animals show a continuous bridge of regenerated bone extending from one edge of the defect to t he other. None of the parietal defects that had been treated with agar ose contained new bone in the central portion.CONCLUSION Our results s uggest an important role of FGFs to promote large cranioplasty repair and support the use of these proteins as an alternative choice for bon e grafts and bone substitutes. (C) 1997 by Elsevier Science Inc.