USE OF HEMOPERFUSION IN EXPERIMENTAL INTOXICATION WITH NERVE AGENTS

The aim of this study was to evaluate the efficiency of hemoperfusion (HP) through coated resin adsorbent Synachrom E-5 in animal intoxicati ons with organophosphate inhibitors of cholinesterases type of nerve a gents. Five anesthetized dogs were intoxicated with 2 to 6 LD50 of VX substance and another 4 with 2 to 3 LD50 sarine. Both nerve agents wer e given i.m. after starting 5 h HP. The clinical and laboratory tests were monitored during each HP. HP therapy prevented the development of serious signs of intoxication provided that the administered quantity of both sarine and the VX substance was only 2 doses of LD50. Specifi c antidote therapy was necessary to prevent cardiorespiratory failure in animals intoxicated with a higher dose of poison. The results obtai ned show that HP through Synachrom E-5 in intoxication with nerve agen ts sarine and the VX type is only partially successful.