THE FRONTAL LOBES AND SCHIZOPHRENIA

Many patients with schizophrenia show clinical signs of frontal lobe d ysfunction, including blunted affect, difficulty with problem solving, and impoverished thinking. The authors present cytoarchitectural, neu ropsychological, and functional neuroanatomical evidence of frontal ab normalities from recent studies of frontal dysfunction in schizophreni a. It is suggested that the failure of intracortical connectivity of t he prefrontal cortex accounts for both cognitive and psychotic manifes tations of this illness.