V. Fernandeztrigo et Ph. Sugarbaker, DIAGNOSIS AND MANAGEMENT OF POSTOPERATIVE GASTROINTESTINAL FISTULA - A KINETIC-ANALYSIS, Journal of experimental & clinical cancer research, 13(3), 1994, pp. 233-241
Gastrointestinal fistula is a major concern after extensive gastrointe
stinal surgery. Thirty three gastrointestinal fistulas in 32 patients
were retrospectively analyzed regarding the diagnosis of fistula and i
ts management. Special attention was directed to the time intervals be
tween surgery and the diagnostic or therapeutic intervention. Onset of
fever occurred an average of 8 days after gastrointestinal surgery wh
ile abdominal pain, leukocytosis and biliary-enteric drainage most fre
quently developed at postoperative day 9. The definitive diagnosis was
made on average at day 14 postoperatively and definitive treatment at
day 19. Diagnosis was made by abdominal CT scan in 25% of patients, c
ontrast enema in 25%, upper gastrointestinal radiologic series in 12%,
and laparotomy in 35% of cases. Although percutaneous drainage was ut
ilized in 18/32 (56%) of patients it was a definitive treatment in onl
y 5 out of 18 (28%). Surgical drainage was required in 40% of the pati
ents. A primary closure by plication of intestinal perforations was pe
rformed in 63% of cases. In addition, forty percent of patients requir
ed early or delayed construction of an ostomy. From this study the del
ay in diagnosis was approximately 5 days and the delay in definitive t
reatment approximately 10 days from the earliest clinical signs of fis
tula formation. No conclusive recommendations regarding diagnosis emer
ged from these data; rather, the simplest tests should be employed fir
st. Early diagnosis and definitive surgical treatment resulted in an i
mproved outcome as compared to late (after the tenth postoperative day
) interventions. An algorithm for fistula diagnosis and surgical treat
ment that utilizes a kinetic approach to management was proposed.