ELEMENTS IN THE LONG TERMINAL REPEAT OF HIV-1 THAT INTERACT WITH NUCLEAR EXTRACTS FROM JURKAT CELLS PERSISTENTLY INFECTED WITH VACCINIA VIRUS

Authors
CHANG PY STELLRECHT K MELANA S POGO BGT
Citation
Py. Chang et al., ELEMENTS IN THE LONG TERMINAL REPEAT OF HIV-1 THAT INTERACT WITH NUCLEAR EXTRACTS FROM JURKAT CELLS PERSISTENTLY INFECTED WITH VACCINIA VIRUS, Virus research, 34(2), 1994, pp. 127-138
Citations number
34
Categorie Soggetti
Virology
Journal title
Virus research → ACNP
ISSN journal
01681702
Volume
34
Issue
2
Year of publication
1994
Pages
127 - 138
Database
ISI
SICI code
0168-1702(1994)34:2<127:EITLTR>2.0.ZU;2-5
Abstract
Previous reports showed transactivation of the long terminal repeat (L TR) of HIV-1 in Jurkat cells persistently infected with vaccinia virus . In this communication, electrophoretic mobility shift assays were us ed to characterize the elements in HIV-1 LTR which might be responsibl e for the mechanism of transactivation. The results indicated that two elements, those for binding NF-kB and NFAT-1, were able to interact w ith nuclear extracts derived from Jurkat cells persistently infected w ith vaccinia virus, suggesting that they may play a role in the transa ctivation of HIV-1 LTR.