IMMUNOREGULATORY PROPERTIES OF HEXAPEPTIDE ISOLATED FROM PORCINE BONE-MARROW CELL-CULTURE

Citation
A. Mikhailova et al., IMMUNOREGULATORY PROPERTIES OF HEXAPEPTIDE ISOLATED FROM PORCINE BONE-MARROW CELL-CULTURE, Regulatory peptides, 53(3), 1994, pp. 203-209
Citations number
18
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
01670115
Volume
53
Issue
3
Year of publication
1994
Pages
203 - 209
Database
ISI
SICI code
0167-0115(1994)53:3<203:IPOHIF>2.0.ZU;2-G
Abstract
Myelopeptide 1 (MP-1) is hexapeptide originally isolated from porcine bone marrow cell culture. It was synthesized and its immunoregulatory properties were studied. MP-1 caused a 1.5-2-fold dose-dependent incre ase of antibody production in the culture of mouse immune lymph node c ells. It abolished Con A induction of T suppressors in the suspension of mouse spleen cells and counteracted the inhibitory effect of T supp ressors on antibody production. The inoculation of MP-1 (1.10(-9) g/mo use) to mice two weeks after their gamma-irradiation (2 Gy) resulted i n an increase of antibody production up to 80.2 +/- 15.5% as compared to that in the irradiated control 37.6 +/- 12.0%. Immunofluorescent an alysis revealed the specific binding of MP-1 with receptors on the tar get cells in the suspension of mouse spleen cells. It is supposed that MP-1 participates in the immunoregulatory processes in the living org anism.