2 UNUSUAL NEUROLOGICAL PRESENTATIONS OF GRANULOCYTIC SARCOMA IN PHILADELPHIA-POSITIVE CHRONIC MYELOID-LEUKEMIA

Granulocytic sarcoma (GS) is a rare extramedullary tumour consisting o f immature myeloid precursors. It occurs most commonly in association with myeloid leukaemias and myeloproliferative disorders. Rarely there may be no evidence of haematological malignancy. We describe neurolog ical presentations of GS in two patients with Philadelphia (Ph) positi ve chronic myeloid leukaemia (CML). In both cases the bone marrow was in chronic phase at the time of presentation of the GS, but there was rapid subsequent transformation into the blastic phase.