A TEST OF BRAIN ELECTRICAL SOURCE ANALYSIS (BESA) - A SIMULATION STUDY

The present report summarizes the results of a simulation study on the accuracy of Scherg's implementation of spatio-temporal analysis (BESA ) for estimating the parameters (wave shape, location, orientation) of the intracranial sources of event-related brain potentials (ERPs) rec orded from the scalp. In view of the subjective factors that might inf luence a solution, 10 subjects, ranging from those with much experienc e with ERPs and extensive background in the use of BESA to those with little experience with BESA and/or no knowledge of ERPs, independently analyzed a set of simulated somatosensory ERP data. The simulation co ntained wave forms from 32 electrode sites generated by a combination of 10 dipole sources. The primary question was how faithfully the diff erent subjects would depict the source wave shapes, locations and orie ntations. Based on the 9 subjects who were familiar with ERPs, the gra nd-average cross-correlation coefficient between subjects' estimated a nd actual source wave shapes was 0.89 (standard deviation (S.D.) = 0.1 7). The grand-average location error, based upon a head diameter of 17 cm, was 1.4 cm (S.D. = 1.0 cm). The grand-average orientation error w as 24.4 degrees (S.D. = 20 degrees).