STUDY OF STRUCTURE-ACTIVITY CORRELATION IN DESTRUXINS, A CLASS OF CYCLODEPSIPEPTIDES POSSESSING SUPPRESSIVE EFFECT ON THE GENERATION OF HEPATITIS-B VIRUS SURFACE-ANTIGEN IN HUMAN HEPATOMA-CELLS

Authors
YEH SF PAN W ONG GT CHIOU AJ CHUANG CC CHIOU SH WU SH
Citation
Sf. Yeh et al., STUDY OF STRUCTURE-ACTIVITY CORRELATION IN DESTRUXINS, A CLASS OF CYCLODEPSIPEPTIDES POSSESSING SUPPRESSIVE EFFECT ON THE GENERATION OF HEPATITIS-B VIRUS SURFACE-ANTIGEN IN HUMAN HEPATOMA-CELLS, Biochemical and biophysical research communications, 229(1), 1996, pp. 65-72
Citations number
23
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
229
Issue
1
Year of publication
1996
Pages
65 - 72
Database
ISI
SICI code
0006-291X(1996)229:1<65:SOSCID>2.0.ZU;2-P
Abstract
A new destruxin [destruxin E2 chlorohydrin] was isolated from the cult ure medium of Metarrhizium anisopliae and its structure was determined by NMR spectroscopy and mass spectrometry. As compared with other des truxins, the new destruxin showed a lower suppressive activity on the production of hepatitis B virus surface antigen in human hepatoma Hep3 B cells. NMR study coupled with molecular modeling by computer graphic s has revealed that the hydrophobicity nature of the convex surface ch aracteristic of all destruxin molecules plays an important role in the ir biological activity. (C) 1996 Academic Press, Inc.