K. Aoki et al., BETA(2)-GLYCOPROTEIN-I-DEPENDENT AND BETA(2)-GLYCOPROTEIN-I-INDEPENDENT ANTICARDIOLIPIN ANTIBODIES IN HEALTHY PREGNANT-WOMEN, Human reproduction, 9(10), 1994, pp. 1849-1851
The purpose of this study was to determine the association between bet
a(2)-glycoprotein I (beta(2)GPI)-dependent anticardiolipin antibodies
(aCL) and beta(2)GPI-independent aCL and their respective relevance to
adverse pregnancy outcomes. Therefore, we prospectively studied 210 n
ormal pregnant women, utilizing a modified enzyme-linked immunosorbent
assay method for beta(2)GPI-dependent and -independent aCL. Seven of
the 210 pregnant women (3.3%) demonstrated evidence for beta(2)GPI-ind
ependent immunoglobulin G (IgG)-aCL. Two patients, who also appeared p
ositive for beta(2)GPI-dependent IgG-aCL, were proven to be false posi
tives. Amongst the 210 patients, not one was thus positive for beta(2)
GPI-dependent aCL. Women with beta(2)GPI-independent aCL demonstrated
no adverse pregnancy outcomes. These results suggest that the presence
of beta(2)GPI-independent aCL is not associated with the presence of
beta(2)GPI-dependent aCL, though it may give rise to false positive re
sults. Since the presence of beta(2)GPI-independent aCL does not appea
r to be associated with adverse pregnancy outcomes, beta(2)GPI-depende
nt assays may represent better markers of miscarriage risk.