LOW-DOSE ASPIRIN COMBINED WITH DIPYRIDAMOLE VERSUS ANTICOAGULANTS AFTER FEMOROPOPLITEAL PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY

PURPOSE: To investigate whether anticoagulation or platelet inhibition treatment provides better prevention of reobstruction after percutane ous transluminal angioplasty (PTA). MATERIALS AND METHODS: In a contro lled study, 160 patients received either oral anticoagulants or a comb ination of low-dose acetylsalicylic acid (25 mg) and dipyridamole (200 mg) (ASAD) twice daily for 1 year after successful femoropopliteal PT A. Compliance was comparable. The patients in the two groups had simil ar clinical and angiographic characteristics. Patency was assessed wit h noninvasive methods 1 day and then 3, 6, and 12 months after PTA and was confirmed at angiography at the end of the study in 112 patients. RESULTS: Patency in patients who received anticoagulants was 53% and was not statistically significantly different from 69% in patients who received ASAD (P = .18). With anticoagulants, there were four bleedin g complications (one was fatal); with ASAD, only five minor complicati ons occurred. CONCLUSION: ASAD is at least as effective as anticoagula nts for secondary prevention of obstruction after PTA but has less sev ere side effects.