EFFECT OF THE CONCENTRATION AND DURATION OF APPLICATION OF MITOMYCIN-C IN TRABECULECTOMY

Ninety-three consecutive trabeculectomies in which mitomycin C (MMC) w as applied intraoperatively, either at a concentration of 0.5 mg/mL fo r 5 minutes (n = 48) or at a concentration of 0.4 mg/mL for 3 minutes (n = 45), were reviewed to determine whether there was a significant d ifference between the two groups in terms of intraocular pressure (IOP ) control and the incidence of complications. Preoperative and postope rative IOPs in the two groups did not differ significantly (P = .817 a nd .131, respectively). The 5-minute group had a higher incidence of s erous choroidal detachments (P = .001). The incidence of postoperative hypotony and filtration failure with uncontrolled IOP in the two grou ps did not significantly differ (P = .177 and .582, respectively). Thu s, intraoperative application of MMC at a concentration of 0.4 mg/mL f or 3 minutes controlled postoperative IOP as effectively as MMC at a c oncentration of 0.5 mg/mL for 5 minutes, with a significantly lower in cidence of choroidal detachments.